Synthesis, Characterisation and pH-Responsive Controlled Release Studies of 5- Fluorouracil Drug from Silica CoatedLao.1Sro.3Mn03Magnetic Nanoparticles
No Thumbnail Available
Date
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Description
One of the drawbacks of some drug delivery system (DDS) is their inability to release their
payloads after reaching the desired site of action. Hence, many DDSs are being evaluated
that are able to release their payloads upon action of an external stimulus. La0.7SrO.JMn03
MNPs were synthesized by solution combustion synthesis and the optimised MNPs were
coated with silica. The synthesized MNPs were characterised by X-ray diffraction (XRD),
thermogravimetry-differential thermal analysis (TG-DTA), field emission scanning electron
microscope (FE-SEM), energy dispersive absorption spectroscopy (EDAX), fourier
transform infra-red spectroscopy (FTIR), vibrating scanning magnetometer (VSM), zeta
potential measurements and ultraviolet-visible spectroscopy (UV-Vis). The anticancer drug
delivery capability of La0.7SrO.JMn03 MNPs was carried out. Silica coatings with were
utilised for the loading of 5-Fluoro uracil (5-FU)- a well-known anti-cancer drug. The silica
surface was functionalised with amino propyl (LSMO-Si02-NH2) to achieve charge
reversal of the designed system from negative to positive as pH varied from 7.4 to 5 which
was used for the effective release of the cargo at endosomal pH 5. The high 5-FU drug
loading and its pH-sensitive release from LSMO-Si02-NH2 suggest that it is a promising
material for targeted drug delivery applications
Keywords
QD Chemistry