Facile Synthesis and Characterization of Substituted Pyrimidin-2(1H)-ones and their Chalcone Precursors
| dc.creator | Ajani, O. O., Ituen, R. I., Falomo, A. | |
| dc.date | 2011 | |
| dc.date.accessioned | 2025-03-06T13:42:27Z | |
| dc.description | A new and efficient method has been developed for the quantitative transformation of chalcones to pyrimidine frame work via solid support catalysis. Silica supported sulfuric acid (SSA) efficiently catalyzes the reaction of α,β-unsaturated carbonyl, chalcones (1-10) with urea to afford substituted pyrimidin-2(1H)-ones (11-20) in good to excellent yield. The interesting behaviour of SSA lies in the fact that it can be re-used after simple washing with chloroform thereby rendering this procedure more economical. The chemical structures were confirmed by analytical data as well as spectroscopic means. | |
| dc.format | application/pdf | |
| dc.identifier | http://eprints.covenantuniversity.edu.ng/1933/ | |
| dc.identifier.uri | http://itsupport.cu.edu.ng:4000/handle/123456789/30046 | |
| dc.language | en | |
| dc.publisher | Pakistan Council of Scientific and Industrial Research | |
| dc.subject | QD Chemistry | |
| dc.title | Facile Synthesis and Characterization of Substituted Pyrimidin-2(1H)-ones and their Chalcone Precursors | |
| dc.type | Article |
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