Evaluation of Biochemical Toxicity and Antioxidant Properties of Pioglitazone on Albino Wistar Rats
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Pioglitazone is one of the thiazolidinedione anti-diabetic drugs which have been used
for the treatment of non-insulin dependent diabetes mellitus. This study aims at
investigating the biochemical effects and safety of pioglitazone (PIO) at various
concentrations in female Wistar rats. A total of 28 rats were randomly divided into
four groups of seven animals each. Groups 1-4 were given 0.5 mL kgG1 b.wt., dayG1 of
distilled water as normal control; 15, 30 and 45 mg kgG1 b.wt., dayG1 of PIO,
respectively as treatment groups 2, 3 and 4, respectively for 28 days. Using standard
biochemical kits and reported chemical procedures, plasma biochemical parameter and
organ lipid peroxidation effects were determined in all the groups. There was significant
increase (p < 0.05) in plasma total protein concentration of group 3 and 4 in comparison
with control. There was also significant (p < 0.05) reduction in total and LDL cholesterols
in PIO-treated groups and concentration of TBARS was reduced in the liver and heart
of PIO-treated groups in comparison with normal control. There was no significant
alteration in the concentrations and activities of liver and kidney function markers of
PIO treated groups in comparison with normal control groups. Pioglitazone at highest
concentration of 45 mg kgG1 b.wt., for the duration of 28 days did not elicit any
measurable biochemical toxicity on non-diabetic rat model
Keywords
QH301 Biology