Leiomyomas: A Review on its Relationships with Transforming Growth Factor–βeta

Abstract

This study investigates the Transforming Growth Factor- Beta (TGF-β)'s role in leiomyoma development. Leiomyomas remain the most common benign tumor traumatizing women especially Black women at the attainment of reproductive age. Reproductive hormones, age, diet lack of vitamin D, are some of the implicated risk factors. However, TGF-β have not been investigated in our population. Different search engines were utilized to obtain articles on the impact of TGF-β and leiomyomas development published in English from 2009 to 2024 by using search identifier keys like leiomyomas, growth genes, TGF-β, uterine fibroid, myomas, and growth factors. Furthermore, indicated articles' reference were checked lists to find further pertinent works on the TGF-β in fibroid development. TGF-β is a cytokine that regulates numerous cell processes including cell differentiation, migration, apoptosis, and cell proliferation are regulated by TGF-β. However, there were inconsistency in the literatures concerning the impact of this growth gene in leiomyomas development thereby creating a gap in knowledge on the impact of this growth gene (TGF-β) in leiomyomas development. Hence, the synthesis of this review's is to advance our understanding on the influence of transforming growth factor Beta in the genesis of uterine fibroid.