Microwave-Assisted Synthesis and Evaluation of Antimicrobial Activity of 3-{3-(s-Aryl and s-Heteroaromatic)acryloyl}-2Hchromen-2-one Derivatives

dc.creator	Ajani, Olayinka O.
dc.date	2010-01-08
dc.date.accessioned	2025-03-06T10:20:00Z
dc.description	The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic chalcones (2a–j) and heteroaromatic chalcones (3a–e and 4a–e), respectively, in good to excellent yield within 1–3 min. The chemical structures were confirmed by analytical and spectral data. All the synthesized compounds were screened for their antibacterial activity and 3-{3-(4-dimethylaminophenyl)acryloyl}-2H-chromen-2-one (2i) was discovered to be the most active at minimum inhibitory concentration (MIC) value of 7.8 µg/mL
dc.format	application/pdf
dc.identifier	http://eprints.covenantuniversity.edu.ng/357/
dc.identifier.uri	http://itsupport.cu.edu.ng:4000/handle/123456789/28985
dc.language	en
dc.publisher	John Wiley and Sons, Inc USA
dc.subject	QD Chemistry
dc.title	Microwave-Assisted Synthesis and Evaluation of Antimicrobial Activity of 3-{3-(s-Aryl and s-Heteroaromatic)acryloyl}-2Hchromen-2-one Derivatives
dc.type	Article

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