Gas chromatography-mass spectrometry identification of anticancer phytochemicals in Aframomum danielli (LB579)

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dc.creatorRotimi, S. O, Bisi-Adeniyi, Tolulope Dorcas, Adelani, Isaacson, Adegbite, Oluwatobi Samuel
dc.date2014
dc.date.accessioned2025-04-01T16:05:45Z
dc.descriptionAframomum danielli is one of the African spices used in folklore medicine for the management of several diseases. This study identified the phytochemical components present in the n-hexane seed extract of the A. danielli by gas chromatography-mass spectrometry (GC-MS) analysis and also evaluated the anti-cancer potential of the identified phytochemicals by performing molecular docking against human Vascular Endothelial Growth Factor (VEGF) using Molegro Virtual Docker. The GC-MS analysis identified the presence of phytochemical components caryophyllene (RT: 18.479), humulene (RT: 19.189), 2-butanone (RT: 22.976), benzenesulfonamide (RT: 31.651) and 2-pyridine acetic acid (RT: 32.446). 2-Butanone was the strongest binding ligand (-65.744 kcal/mol) while caryophyllene was the weakest bind lingand (-56.311 kcal/mol). These compounds showed relative strong docking to VEGF with docking energies comparable to an anticancer drug, bevacizumab (-77.883 kcal/mol). This in silico molecular docking study has shown that these phytochemical components could be responsible for anti-cancer properties of A. danielli.
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dc.identifierhttp://eprints.covenantuniversity.edu.ng/10485/
dc.identifier.urihttps://repository.covenantuniversity.edu.ng/handle/123456789/39954
dc.languageen
dc.subjectQ Science (General), QH301 Biology
dc.titleGas chromatography-mass spectrometry identification of anticancer phytochemicals in Aframomum danielli (LB579)
dc.typeArticle

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