Recent Advances on the Management of Parkinson’s Disease: A Review
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Parkinsonʼs Disease (PD) is a progressive neurodegenerative disease associated with loss of
dopamine-producing cells and characterized by tremors, stiffness and bradykinesia. The cause of PD is unknown, however, both genetic and environmental factors play a role in the pathophysiology. In this review, Ghrelin mediated neuroprotection, the use of exenatide and
bee venom as recent developments in the management of Parkinsonʼs disease was discussed. The presence of Lewy bodies and α-synuclein in Lewy bodies has also been contraindicated in the progression of this disease. Parkinsonism is considered to arise primarily from
abnormalities of basal ganglia function. Although Parkinsonʼs disease cannot be treated, its progressive symptoms could be delayed by several methods which include the use of anticholinergic agents, amantadine levodopa, monoamine oxidase inhibitors, catechol-O-methyltransferase inhibitors and deep brain simulation. Despite numerous research on PD, more recent and less evasive mechanisms have been researched upon to nderstand the root cause of this disease. In this study, the possible cellular and molecular mechanisms fundamental to the action and possible role of ghrelin, exenatide and bee venom in slowing or preventing Parkinson's disease progression was considered.
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Q Science (General)