In vitro antibacterial and antifungal activities of Chrysophyllum albidum and Diospyros monbuttensis leave
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Despite progress in the development of antibacterial agents, there are still special needs to find new
antibacterial agents due to the development of multidrug resistance by bacteria and fungi.This study
was conducted to investigate and compare the in vitro antibacterial and antifungal activities of the
methanolic and ethanolic extracts of the leaves of Chrysophyllumalbidum and
Diospyrosmonbuttensis.Methanolic and ethanolic extracts of D. monbuttensis and C. albidum leaves
were prepared using cold extraction method. Antimicrobial sensitivity testing was carried out using
agar-well diffusion method against the following test organisms: Staphylococcus aureus,
Streptococcus sp., Escherichia coli (Enteropathogenic), Klebsiellasp., Candida albicans and
Aspergillusniger. Minimum inhibitory concentration of the extracts of D. monbuttensis and C. albidum
leaves was determined using broth dilution method. S.aureus, Streptococcus sp., E. coli
andKlebsiellasp. were sensitive to ethanolic leaf extract of C. albidum at 25, 50 and 100mg/ml
respectively. Streptococcus sp.,E. coli (Enteropathogenic), Klebsiellasp. AndC. albicanswere sensitive
to C. albidum at 25and 50mg/ml. A. niger showed resistance to both extracts at the different
concentrations used. The MIC of the methanol and ethanol leaf extracts of D. monbuttensis and C.
albidum against the test microorganisms ranged between 3.125 and 100mg/ml. This is indicative that D.
monbuttensis and C. albidum leaf extracts can be used in the treatment of infections
Keywords
QH301 Biology